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In "From Philanthropy to Social Investment: A New Way of Giving," I discussed how the emergence of new philanthropic funding models allows strategic philanthropists to have a greater impact on the causes they care about most. Alongside traditional non-profits, these newer models --  income-generating non-profits; for-profit social ventures; socially responsible businesses; and carefully screened, traditional for-profit businesses -- form an ecosystem that provides multiple ways of addressing a single problem. (Sophisticated philanthropists, like Bloomberg Philanthropies, often partner with the government to solve key issues, as well.)

In many respects, these five models are similar to investment asset classes, each with their own specific role to play. Just as no single asset class can provide the growth or asset protection necessary in a well-constructed investment portfolio, no one funding model can fully address the various complexities of a systemic social issue like homelessness, illiteracy, or protecting the environment.

As in investing, donors are wise to construct a diversified "philanthropic portfolio" that utilizes these models to varying degrees in accordance with their long-term philanthropic and wealth goals. Doing so can help donors move beyond simply addressing the symptoms of a social issue to get at the deeper root causes.

Developing a Framework

In order to build an effective philanthropic portfolio, a donor must first understand the strengths of each funding model, their unique applications, and the differences between them.

 

The best way to illustrate this is to frame it in terms of a particular issue. Take homelessness, for example. A typical donor who is concerned about homelessness likely donates to traditional non-profit organizations, such as shelters, soup kitchens, and food pantries. Organizations like these provide vital and necessary services to those struggling with homelessness, but they are primarily focused on addressing the symptoms of homelessness -- not its root causes. It's only one piece of a very large, complicated puzzle.

For a donor interested in addressing the totality of homelessness and not merely its immediate effects, a broader approach is needed. Looking at the larger issue, the donor might identify a number of smaller issues that must be addressed to effectively combat homelessness: a lack of affordable housing, a poor job market, a lack of access to educational opportunities, or affordable daycare. A multifaceted problem requires a multifaceted solution.

While designing such a solution might seem daunting, it's simpler than it may first appear. The key to this process is remembering that it is iterative. Donors should take a phased approach that starts small and gradually evolves into a full-fledged philanthropic portfolio that suits both the issue at hand and the donor's circumstances.

Start Simple and Be Strategic

Donors shouldn't feel compelled to jump in headfirst and start funding all five types of models immediately. Instead, they should choose the most familiar areas, which can serve as a foundation for the addition of more complex or advanced models down the road.

For most people, this will likely mean funding traditional and income-generating non-profits, as well as making selective investments in for-profit companies.

For example, a donor beginning to put together a philanthropic portfolio aimed at addressing homelessness might start by funding non-profit homeless shelters in their area and loaning money to an income-generating non-profit that operates a low-cost health care clinic for economically disadvantaged people or a job placement agency.

They may also wish to recalibrate their investment portfolio to ensure they are not investing in traditional for-profit companies that may be exacerbating the problem they wish to solve -- for example, a financial institution that engages in predatory lending.

These first steps represent an entrée to the more advanced models, namely, for-profit social ventures and socially responsible businesses.

Profit for a Purpose

It can sometimes be hard to distinguish between for-profit social ventures and socially responsible businesses, as they have a lot in common. However, the distinction is important.

Essentially, a for-profit social venture is a business that makes a particular social outcome -- say, addressing homelessness -- the centerpiece of its efforts. For example, Find Edmonton is a Canadian furniture company that sells furniture to consumers at a profit, and then uses those profits to provide furniture to people who are just emerging from homelessness free of charge. The profit motive and the charitable motive are one and the same. These ventures are sometimes referred to as double- or triple-bottom-line businesses, as they measure themselves not only on fiscal performance, but also on their social and/or environmental impact.

For a socially responsible business, profit is still the main motive. However, these businesses make an effort to ensure that their pursuit of profit takes social welfare into account. Fig Loans, a Houston, Texas-based company, offers installment loans for low-income Americans who might otherwise need to rely on predatory payday loans. Fig Loans makes little to no money on the loans themselves; instead, they provide a fair price on small loans up to $800. This allows the recipient to manage a financial crisis without resorting to predatory lenders and repay the loan in the shortest amount of time available. By partnering with non-profit organizations, Fig Loans earns profit by building up their customers' credit scores over time and then referring them to traditional banks. Rather than taking advantage of a vulnerable group of people in pursuit of profit, their business model incentivizes them to better the lives of their customers.

Fig Loans, like many socially responsible businesses, is a certified "B Corporation," which is a private certification that tracks and measures how effective a company is at achieving its social and environmental goals. The certification is administered by a non-profit organization, B Lab.

Organizations such as these need more direct help and involvement than those in the other categories. Donors may want to co-sign a line of credit or make a direct investment in return for equity in order to provide these ventures with the capital needed to get off the ground.

Identifying the Right Funding Vehicle

Once donors determine what they want to fund with their philanthropic portfolio, they must then determine the right vehicles to carry out the funding. There are several options:

 

Each of these vehicles can be useful to donors interested in funding the ecosystem, though donor advised funds, private foundations and charitable LLCs offer the most flexibility. Charitable LLCs are perhaps the most flexible, as donors can take the income tax charitable deduction when they distribute from the LLC, rather than when they fund it, as is the case with a donor advised fund.

Ultimately, each of these vehicles can be invested according to a specific, values-based mandate set out by the donor. Utilizing multiple vehicles and aligning each with a specific funding goal within the ecosystem, known as "stacking," can be particularly effective.

Conclusion

While tackling large social issues and causes can be daunting, the framework that donors develop around these new funding models offers a greater sense of control and accomplishment. By recognizing the complexity of these issues, donors can confront each facet of their chosen issue with a purpose-specific tool that can make the overall mission seem less overwhelming.

In the end, finding meaning and purpose in how wealth is deployed for philanthropic ends is a balancing act, and the "philanthropic portfolio" approach is one method that donors can use to find that balance.

The views expressed herein are those of the author only and do not necessarily reflect the views of BNY Mellon. The content hereof is for informational purposes only and does not constitute investment, legal, tax, or financial advice.

 

Meet Avery Fontaine. Avery’s background encompasses brokerage, corporate finance, charitable trust administration and philanthropic sales. She holds a Philosophy/Art History degree and MBA which together combines to bring extensive knowledge and background to her role as Head of Strategic Philanthropy for BNY Mellon Wealth Management. 

Listen to the podcast version of the Q&A here.

Q: How did you come to this field? 

A:  It was an iterative process. I worked in nonprofit development early in my career and was struck by the huge responsibility of creating revenue flow for the arts, an area for which I care deeply. At that stage in my career, I was very uncomfortable asking wealthy families to give large sums of money when I knew very little about their overall picture of investments or planning. I often wondered aloud, how could I help them make sound decisions? So, I started as a broker in the late 90’s to learn firsthand investment management. As I got better at time, project, and resource management, I craved more meaning in my work. That’s when I discovered Greg Dees’ whitepaper, “The Meaning of Social Enterprise,” and had an a-ha moment. Being productive or revenue-focused and solving a real problem were not mutually exclusive goals. I lucked out and got to learn from him at The Fuqua School of Business at Duke University. My work in a philanthropic services group after grad school only solidified my belief that deploying capital to solve real problems was expanding across a spectrum of models for investment.  

Q: Can you talk about the state of the philanthropic market in the United States? 

A: It’s changing rapidly. Donors have multiple levers to pull in order to achieve their goals, and nonprofits are catching up to donor demand by partnering together, and across the investment spectrum, collaborating with for-profit and nonprofit models alike. Everyone is learning together, in the best scenarios. In more challenging environments, tension still exists between traditional and new methods. 

Q: What are the forces you see creating change in U.S. philanthropy? 

A:  Age demographics certainly play a role. We have five generations operating simultaneously right now. Each is very different, with unique pressures and goals – How can we best work together for the benefit of all?  

New Funding Models: Those generational differences have given rise, in part, to new ways of funding social endeavors. Instead of focusing on the pure nonprofit operating model, philanthropy becomes part of a portfolio approach to expressing social values. There are new levers to pull -- investing debt or equity in the form of direct investment in early stage social ventures and private B Corps, pay for success structures or loan guarantees in both for-profit social ventures and nonprofits -- to name a few.

Tax Code & Jobs Act: While the new tax code doesn’t change philanthropically minded individuals’ plans, we see greater interest in new strategies to deploy capital for good. As such, we often hear from our clients that traditional grantmaking isn’t as meaningful to them. They want to be part of a solution. Either they feel a bit helpless that they can’t be a mega donor and wipe out global issues like malaria, or they have analysis paralysis and aren’t sure where to begin. It can be overwhelming. The new tax code doesn’t inspire charitable intent, necessarily. But handled well, the successful conversation focuses on values and how best to look at areas of interest coupled with multiple avenues open to that particular family. Income reduction plus values integration, instead of tax avoidance, then becomes a key part of the vehicle choice and direction. We see an increased use of the Donor Advised Fund and Charitable LLC. People want anonymity and flexibility while they try new things.  

Q: How do you find this intersecting with impact investing? 

A: Obviously, impact investing, as defined by direct funding of a for-profit social venture, is a key part of this conversation. It’s a new tool. The hard part is finding the opportunities for investment.  

Q: Can you talk about what this ecosystem looks like for social ventures? 

A: For our families interested in funding for-profit social ventures that support the environment, for example, we look at the local ecosystem first. Is there a double or triple bottom line incubator in town? How are they organized? Can our family volunteer or what kind of introduction can we make? Usually we have strong ties to the academic community, and many social venture incubators or accelerators are part of the local business school or economic development initiatives. Co-working spaces, meetups, and groups like Social Innovations Journal are more connected now than ever. Many communities are actively building databases of social entrepreneurs for donor/investor use. Wouldn’t it be great to do this nationally? A new marketplace, perhaps? Organizations like Social Enterprise Alliance, Skoll Foundation, and Ashoka (note to layout team – hyperlink recent Ashoka edition) have been doing this work for more than 15 years, and are great resources.  

For families with significant assets, I encourage them to recognize this is an iterative process. Let’s start with nonprofit funding and an ESG portfolio and use that combination as a springboard to connecting to the local entrepreneurial scene as well as regional and national social venture funds. For family offices, the CIO often researches the various member interests. My job at that point is to add value as a connector to new people, ideas, and strategies. So, yes, the ecosystem remains young and fragmented. But that’s exciting to me -- to be part of the maturation process.  

Q: How can an impact investor or philanthropy best align their portfolio with social ventures across the spectrum/returns continuum? What does this look like in tackling a particular social issue area? What about improving a place/neighborhood?  

A: Take arts and culture funding, for example. Out of a foundation, DAF, charitable llc, or charitable trust, a family may choose to make grants to the museum, ballet, symphony, or opera. They may even create a prize model like the MacArthur Genius Grant. Moving along the spectrum, they could fund a nonprofit with a revenue-generating model by loaning money to restore an historic theater in a community revitalization project. Or they may grant to a Community Development Finance Institution (CDFI) that lends money to early stage entrepreneurs and stipulate the grant funds go towards those models focused on the creative economy (digital marketing firms, artisans, or ironworks/foundry models). For impact investing, they may invest debt or equity into a gaming or virtual reality startup that uses a design-centered model to solve a problem like mental health for teens. Or fund an affordable artist space and real estate development in an urban area. For B Corps, private or public, they could invest in models like Etsy, Patagonia, Kickstarter. Another option is to invest in social venture funds aggregating creative economy business models like Upstart Co-Lab. Lastly, food security, environmental solutions, education, and economic development solutions all depend upon creative, design-centered innovation. Buying shares of those large, publicly traded companies across industries who rely on such innovation to thrive is one way to tilt an investment portfolio.    

Q: Can you speak about what this means for different generations and the opportunity to connect different generations through philanthropy?  

A: The challenge and the blessing is that no two families are alike. But there are generalized qualities and differences between generations that hold up. Millennials and baby boomers see the world very differently, often at odds with one another. The best option to help families rise above conflict is to help them connect back to the values, origin stories, and family lore that they alone share. What makes that family unique? Help them connect to that, and then find the common ground philanthropically. If there are strong authoritarian structures within a family, those are difficult to overcome. But there are ways to manage it. Often the practice of philanthropy itself can be a bridge-builder; connecting over our shared humanity, thinking in centuries vs decades, can be a powerful force.  

Q: How can we better develop this market to unlock and move capital to where it is most needed?  

A: With the GIIN estimating the impact investment market currently at $502B, which is $100B more than the U.S. domestic philanthropic market as of June 2018 of $410B (source: Giving USA), no one can logically dismiss impact investing as a fad any longer. The big issue is scale. Is the impact investing arena to remain a small batch, place-based investment opportunity? Would that be a bad thing? How can large pensions, endowments, and 401K plans find opportunities to fund early stage social entrepreneurs in a private equity or debt-like model? They can’t do this easily right now. Why? Two reasons: first, companies with social vision struggle with the capacity to put large sums of money to work, to scale. And second, the process of finding, doing due diligence, and planning for exit often looks very different for double or triple bottom line models. There is no standard model yet. While an established public company can certainly show progress with measuring adherence to the UN’s SDG’s and even go one step further to become a B Corporation, the earlier stage ventures are in new territory. The B Corp model may well be our best hope – they have a standard of audit reporting. Of course, this is where the opportunity lies: creating a demonstrable, repeatable process for evaluation, investment and exit.  

Q: What does a successful "exit" look like for a social venture? 

A: It depends. Some are solving problems, like predatory payday lending, that may always have a market. They can scale and merge with other financial institutions if they choose. Others may be solving a problem in disease care/eradication where new technology may outpace them, or where the goal is to go out of business by solving the problem. The important thing to remember is that a good business model solves a problem, and savvy leaders find a way to evolve and solve new problems instead of institutionalizing suffering. In this era of social media, perpetuating a problem simply for profit is a risk most are unwilling to take.  

Q: What do you see for the field in the coming year? 10 years? What do you see as some challenges/roadblocks? What are you most excited about?   

A: The business of advising families on their social purpose and impact strategies is just getting started. Likewise, for nonprofits and their leadership. It’s an exciting time. I’d like to see more integration within the nonprofit community across a spectrum of models. We don’t want nonprofits to lose their unique position and identity; I see the sector becoming an evolving resource for donors with more deliberate partnerships and strategies across a broader range of models. I also look forward to those conversations with our families as these concepts become more normalized. The estate planning and CPA communities are just beginning to notice a difference in client demand as well. The biggest challenge is education, and that is rapidly overcome as the next generations both influence their families’ decision making and take over family operations.  

* * *

 

Every day, all of us read about early-stage success with research curing cancer, restoring vision, healing damaged hearts, renewing mental health, or restoring physical mobility. And each day when we read these stories, each of us thinks of someone we love and wish research could move faster. With more money for high-quality biomedical research, it will. With Bio Bonds, the institutional investors now largely on the biomedical-research sidelines, will finally be able to fund perhaps our most critical social-welfare goal: lengthening life, easing suffering, and facilitating independent, productive living. Legislation now moving through the U.S. Congress could make Bio Bonds a billion-dollar market reality in the next year or so, paving the way to a new social-impact construct in which the billions of institutional dollars now locked out of social-impact investing fund high-quality biomedical research secure in the knowledge that a federal guarantee backs half the risk.

Bio Bond Basics

There are indeed many investors hoping to do good along with doing well with their dollars. Much work is also underway to make it easier to do good with environmental, social, and governance (ESG) obligations by improving disclosures, increasing asset-manager certainty, and creating a clearer legal framework for pension funds and other fiduciaries. However, it will always be challenging to raise real money -- the billions needed for biomedical research, very much included -- if bonds or other financial vehicles do not earn a rate of return close to or equal that of a like-kind investment with a similar risk profile. As green bonds proved, unlocking the key to the financial market’s own demand for money-making instruments creates huge balances of new investments that then accelerate critical ESG objectives.

How did this work for green bonds? Despite the widely-shared goal of reducing fossil-fuel dependence and global warming, funds for sustainable energy-and-environmental programs were scarce until the World Bank guaranteed the first of what we now call green bonds in 2007.1 Depending on how the market is measured, it has grown since then to at least $580 billion in total issuance through 2018.2 The reason for these hundreds of billions is not that sustainable finance suddenly got safer, but that the World Bank guarantee encouraged other governmental backstops that reduced risk to the point that institutional investors believed that their fiduciary duties were satisfied along with their own personal hopes of a greener, cooler planet.  

And, the more knowledge institutional investors gained about green finance with these backstops, the more confident they became, the more the money flowed, and the less need there was for a governmental safety net. The majority of the most recent green-bond issuances are freestanding private-sector capital-market offerings held not only by social-impact focused investors, but also across the entire spectrum of investors looking for the particular risk/return package individual bonds present. The market now is also facilitating efforts to increase the size and depth of the green-bond market, with trade associations in March of 2019 pioneering definitions for loans that ensure that these extensions of credit meet sustainability goals.3

Importantly, green bonds are almost exclusively debt instruments -- that is, the investor takes a stake in a bigger loan to the bond’s beneficiary (i.e., a solar-energy producer). Institutional investors -- i.e., pension funds, life-insurance companies, most asset managers -- are generally reluctant to take an ownership -- i.e., equity -- stake in commercial ventures because of the far greater risk involved. As a lender, you are repaid, or the fund beneficiary is forced into bankruptcy and you as the lender get at least a bit of your money back. As an owner, all your money is gone in the bankruptcy, leaving you little financially but in contrast a lot of residual liability for risks such as any environmental damage the project may have caused in the interim. 

How Would Bio Bonds Work

Starting with a pilot bond program to speed treatments and cures for blindness, Bio Bonds harness billions in institutional capital with the backing of a limited guarantee from the U.S. government. Many nations now have similar guarantees for equity investors in “translational” biomedical research -- that is, research bridging the gap between basic work with test tubes and mice and research demonstrating safety and efficacy in people.4 However, there is no such program in the U.S., in part because the U.S. Government (USG) has a strong aversion to anything akin to an ownership stake in a private venture. This is not only because equity stakes are riskier, but also because U.S. policy is premised on sharper distinctions between public and private finance than is common in many other nations. Yet, the U.S. has a lengthy history of backing guarantees for debt instruments, including the almost $7.3 trillion of mortgages now backed by the U.S. taxpayer5,6,7 energy loans, as well as  those to small businesses.  

As detailed below, the Bio Bond construct works within the confines of U.S. policy to craft new laws to create truly translational funding for under-funded biomedical research -- that is, private capital investment that bridges the gap between direct government spending for basic research and high-return, short-term biomedical-funding sources such as those provided by venture capital (VC) firms. Pending legislation, the “Faster Treatments and Cures for Eye Diseases Act,” is the legislative vehicle that brings Bio Bonds into the market. Here’s how it works.

The Valley of Death

Media are replete with reports that excite hope about dramatic new medical treatments -- “Blind Mice See” or, “First-Ever Patient Cured of Deadly Cancer.” And, then, it seems to and often takes decades before a promising treatment or cure is approved for widespread use. The period between promising basic research and drug approval/commercialization is called the “valley of death” in biomedical circles because it’s where viable research dies all too often not due to a lack of scientific merit, but because of the dearth of funds.  

Federal spending such as that from the National Institutes of Health (NIH) and patient charities fund much of the basic research needed to test hypotheses and then to ready research for clinical testing -- that is, for formulating drugs to test dosage, safety, and -- of course most importantly -- efficacy. But clinical trials cost millions in order to ensure rigorous testing, patient safety, and sufficient sample size.  

And, the more progress a treatment or cure takes, the more it costs -- drug development from initial pre-clinical work to final approval on average costs $2.6 billion.8 Biopharmaceutical and VC firms come in towards the end of this process, cherry-picking the most promising treatments for the largest patient populations requiring the most pills at the highest cost for the biggest impact in comparison to other possible treatments and cures. Most of these firms generally do not come in as the valley of death dawns before a promising biomedical researcher because they don’t lend money; they instead make equity investments that give them ownership rights over a drug or device. These rights are of little value if one has to wait years to know if there will be any return on investment -- the earlier the investment, the greater the return, but the greater the risk -- and then some.

I have seen the quicksand in the biomedical valley of death all too clearly from my perch as a director of the Foundation Fighting Blindness (FFB). FFB is the leading source of private-sector, philanthropic funding for treatments and cures of inherited retinal disease (IRD). Although it seemed for years that scientists had done little more than breed another mouse with another type of IRD for testing purposes, the field has taken off in just the last few years. One reason is not only the personal, family, and economic hardship wrought by blindness, but also the fact that the retina is often called the “window to the brain.” Testing drugs, gene therapy, and stem-cell treatments in the retina is a way scientists can literally see what a treatment does; similar observation in a living brain is often difficult, if not impossible. This has sparked a raft of extremely promising research, but FFB -- despite resources well above those at most patient foundations -- can fund only a small number of the projects its scientists believe could make an important difference.  

At a meeting in which the FFB explored the gap between deserving science and the funding to move it forward, a group of venture capitalists said that, as much as they would like to invest early in the biomedical process, their business model does not allow it. Their investment timeframe is short -- three to five years -- and their return on investment is high -- usually at least 20 percent. Too many projects take too long, cure too few patients, or do so at too low a price to warrant VC investment, especially long before proof of success is readily apparent.

Extensive financial-market research bears this out. Andrew Lo at the Massachusetts Institute of Technology (MIT) has been a pioneer in this field, charting the funding gap for cancer9 and proposing a novel investment vehicle to encourage institutional investors to speed treatments and cures in this life-or-death field.10 However, years after his ground-breaking research, institutional investment remains largely sidelined from translational biomedical research, leaving the valley of death almost as deep and its quicksand almost as deadly as before.

Seeing the Way with Eye Bonds

The following graphic shows one example of how Eye Bonds would work and thus how they chart the path forward to Bio Bonds. The steps below occur after an Eye-Bond has been “floated” (i.e., sold to investors), providing the $250 million of funding used for cures and treatment fighting blindness as discussed below.

1.  A trust is created to lend money to eligible projects selected by the National Eye Institute (NEI) under terms and conditions that prioritize likely cures and treatments and protect the taxpayer. NEI expenses for project selection are reimbursed (say for $1 million) from bond proceeds so that the taxpayer does not pay for any administrative costs. The cost of underwriting and issuing the Eye-Bond (to be determined by rule, e.g. $5 million) are also deducted before proceeds are distributed to researchers, leaving at least $244 million for cures and treatment.

2.  The Eye-Bond has a maturity of 20 years with no interest due until the maturity date. The bond does earn interest at a preset rate (e.g., five percent annually), but the interest payments accrue for 20 years at which time they are payable to the investors. The bond carries a partial federal guarantee equivalent to no more than 50 percent of the principal (e.g., $125 million).

3.  As a loan for a project is repaid, the trust may invest the proceeds in approved securities until the bond comes due and is also free to make loans to a new project deemed acceptable by NEI and the underwriter.

4.  All cash proceeds received from the repayment of an Eye Bond are first used to reduce the amount of principal guaranteed by the government and the government has a senior claim on all assets and collateral under the Eye Bond to the extent the guarantee has not been extinguished. In practice, this means that the trust will notify the Treasury Department at the time when the assets it has in hand are equivalent to the amount of the Federal guarantee of the Eye Bond (i.e., $125 million using the example above). At that time, the Federal guarantee of the Eye Bond principal will end along with any taxpayer risk and the payment of principal and interest to the eye bond investors will come solely from the assets held in the trust.

1. A Limited Focus on Blindness

Ideally, new U.S. law would kick-start the Bio Bonds market as a whole to speed treatments and cures for a wide variety of diseases and disabilities. However, the huge scale of biomedical research, the all-too-many diseases and disabilities it confronts, and the cost of successful research doom so ambitious an initiative from both a political and policy perspective. We know from the financial research cited above that risk to both taxpayers and investors dramatically increases if an investment pool includes a little blindness, a little cancer, a degenerative muscular condition or two, and a few other syndromes of varying causes, patient populations, severities, and likely cures. Perhaps private bonds someday will cover lots of diseases in a single financial instrument, but investor and taxpayer protection now has to come from a targeted group of projects selected by experts with knowledge across a single, but entire field of biomedical research to increase the chances that as many projects as possible will succeed. After projects are selected, a financial institution determines which biomedical researchers want loans to fund these projects, how much makes sense, and whether the borrower has the capacity to repay the loan even if the drug or device doesn’t work. Loans to eligible projects are then crafted into bonds up to a dollar amount small enough to make taxpayer risk acceptable and big enough to diversify risk across a spectrum of different projects aimed at a single outcome: sight in this case.  

And, finally, the bond program must be big enough to make a meaningful difference to patients and their families -- small gains in scientific research are all to the good, but real progress only comes with real dollars. Real dollars are also necessary to get the attention of top-quality financial institutions and deep-pocketed investors. Eye Bonds now and Bio Bonds to come cannot be “one-offs” -- the program must be big enough to create a deep, liquid pool of continuous low-cost, long-term financing for translational biomedical research.

2.  Why Blindness

There’s no particular reason to start with blindness other than we thought of this construct in connection with the challenges facing the Foundation Fighting Blindness. We know, though, that to prove the viability of this new biomedical-financing instrument and at the same time limit taxpayer risk, we need to start with a clear target: i.e., one over-arching syndrome in which varying causes work through similar mechanisms known well in a defined biomedical field. Eye Bonds legislation picks one well-defined field -- ophthalmology -- and establishes a high-quality source of expertise -- the National Eye Institute (NEI) -- as the arbiter of projects ready to move from basic to translational trials that would then be funded by private investors backed by a federal guarantee.  

Vision research has the advantage of subsuming many types of causes -- injury, diabetes, neural damage, structural defects -- and many possible cures -- drugs, gene therapy, stem-cell treatments, and even whole-eye transplants. Severe vision impairment and blindness also have many sufferers -- an estimated 4.24 million adults in the U.S. alone.11 Blindness also has a particularly pernicious impact on economic independence for both older Americans fearing loss of independence due to reduced sight and younger people struggling to succeed in the work force. 70.5 percent of working-age blind adults are not employed full time,12 with vision impairment costing the U.S. economy an estimated $138 billion per year.13 

With NEI (part of the NIH) picking scientific projects, Eye Bonds solve for the cost of selecting top-flight research. By focusing on one field, Eye Bonds ensure both measurable risk and diversification, enabling the structuring of viable financial instruments. However, Eye Bonds meets investor demand in one other critical way: the government backs debt, not equity stakes in biomedical-research firms. An equity investor wins or loses it all if a biomedical project succeeds or fails; a lender gets its money back as long as the researcher has the capacity to repay. This makes the cost of funding lower and bond terms can be for a longer time period. Importantly, the final cost of a drug or device is likely to be less because long-term -- not high-risk, high-return -- funding backed a treatment or cure.

3.  A Billion Dollar Guarantee for a Five-Year Trial

Pending legislation, the Faster Treatments and Cures for Eye Diseases Act, reflects all of the facts above by sending up a trial balloon that, if it floats for investors and the federal government, will prove the Bio Bonds proposition. The bill authorizes a $1 billion Eye Bond program over five years with the following key terms and condition:

  • Eye Bonds would start up during the first year in which a set of tough rules would be set by the Department of Health and Human Services (HHS) in concert with the Department of the Treasury and, in several cases, the Securities and Exchange Commission and bank regulators. These rules -- which will be tested by annual reports to Congress from the General Accountability Office (GAO), demand strict adherence to statutory taxpayer-protection provisions along with a single-minded focus on curing blindness.
  • Over the next four years of this five-year pilot, as much as $250 million in Eye Bonds per year will be issued for a total of up to $1 billion in eligible instruments. The legislation expects these to be bonds comprised of loans to numerous eligible researchers, but terms and conditions are not detailed to ensure flexibility to identify ways to attract investors without increasing taxpayer risk. One unbreakable rule, though, is that bonds are issued by private financial institutions under the rules described above, not by the Treasury, avoiding any confusion with direct USG obligations.
  • As noted, the National Eye Institute, an arm of the National Institutes of Health, will pick the projects eligible for Eye Bond funding. It won’t determine a borrower’s capacity to repay -- the financial institution underwriting the bond would do that -- but it will survey the entire landscape of U.S. vision research to pick the projects most likely to treat and cure blindness or severe vision impairment. Many of these projects began with basic funding from NEI. As a result, Eye Bonds leverage the taxpayer’s intellectual capital in biomedical research to ensure that great science isn’t left behind due to scant funding.  
  • Each bond would be backed by a full-faith-and-credit USG guarantee for as much as 50 percent of the principal amount of the bond. As payments from borrowers come in, these would be set aside, with investors entitled only to proceeds above and beyond any risk taxpayers absorb.  

4.  Negligible Federal-Deficit Impact

As the Eye Bond legislation was crafted, a lot of thought went into how it will be “scored” -- that is, judged for purposes of its federal-budget impact. With the U.S. deficit growing to record heights, the less a proposal costs, the better its chances of enactment.

It is likely that the Eye Bond legislation would score at only a small cost to the U.S. Treasury, if indeed it is deemed to cost anything at all. There are start-up costs -- i.e., those for writing the rules and for setting up NEI’s project-selection process (which might well include outsiders with translational-biomed expertise). However, bond proceeds in the first year would pay back any such appropriation and bond proceeds going forward would do the same for still smaller administrative expenses. The costs of the private financial institution underwriting the bond and the “trustee” managing it on behalf of the taxpayer and investors also comes from bond proceeds, as is usually the case with fully-private financial instruments.

The big risk of course is that some or all of the 50 percent guarantee gets called. For this to happen, losses first would have to be more than half of the bond principal since, as noted, investors are only entitled to be repaid by the USG for $50 out of $100 of principal if things go awry. Losses of this magnitude are unlikely to happen due to the diversification and focus of the bonds (see above), but there are also additional buffers to protect both investors and the taxpayer. The most important of these derives from the fact that the financial instruments in an Eye Bond are most likely to be debt and debt must be repaid even if the project being funded fails to meet its goals. Equity investors only win if a drug goes to market; secured lenders are repaid no matter what and take steps to obtain the collateral securing their bonds if payments fall short. Should this occur for a borrower within the Eye Bond debt pool, the bond trustee would move in, require the borrower to repay, or receive bond collateral -- e.g., intellectual property -- to honor at least some of the outstanding obligation. In short, it’s like your mortgage -- fail to pay and the bank gets your house.

Curing Blindness and Beyond

Top ophthalmic scientists have told me that a billion dollars will cure blindness for almost every patient in no more than 10 years. This would of course be a miraculous sight, and not only in the U.S. Worldwide, there are at least 36 million blind individuals and another 217 million with moderate to severe vision impairment,14 with the obstacles to economic independence even more formidable for many outside the U.S. A cure to blindness would also open the world’s beauty to those who have never seen it before and those who remember it all too well despite subsequent vision loss. Surely, this is an important social-welfare objective on par with sustainable energy, affordable housing, enhanced education, and many other worthy focuses of social-impact finance and federal spending.

To gain this hope of vision, the worst that can happen to investors is that they lose 50 percent of their initial principal investment -- a high cost, but one that happens every day in the financial market. $500 million is a miniscule drop in the institutional-investment bucket, which amounts to more than $93.8 trillion worldwide.15 The worst that can happen to taxpayers is that we lose $500 million, a lot, but again a minuscule portion of a federal budget of $4.5 trillion of planned spending in fiscal 2019.16 

What’s the best that could happen? It’s even better than just curing blindness. Successful Eye Bonds will pioneer Bio Bonds and Bio Bonds will speed treatments and cures for much of what ails us. Wouldn’t that be something. 

Works Cited

1 Hagan, Shelly, “Green-Bond Sales Surge Toward Record as Borrowers Burnish Brands.” Bloomberg. July 18, 2018. Accessed March 20, 2019. www.bloomberg.com/news/articles/

2 Pronina, Lyubov, “What Are Green Bonds and How ‘Green’ Is Green?” Bloomberg Businessweek. March 24, 2019. Accessed March 26, 2019. www.bloomberg.com/news/articles/

3 Loan Syndication Trading Association (LSTA), Loan Market Association (LMA), and Asia Pacific Loan Market Association (APLMA), “Sustainability Linked Loans Published.” LSTA. March 20, 2019. Accessed March 27, 2019. www.lsta.org/news-and-resources/news/

4 Shaw, Matthew and Drake Palmer. Overview: Translational Biomedical Research Funding in Advanced, Market-Based Economies. Washington: Federal Financial Analytics, 2018. Accessed March 20, 2019. eyebonds.com/wp-content/uploads/

5 Federal National Mortgage Association (Fannie Mae), Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934. Fannie Mae. Form 10-K. February 14, 2019. Accessed March 27, 2019. www.fanniemae.com/resources/file/.

6 Federal Home Loan Mortgage Corporation (Freddie Mac), Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934. Freddie Mac. Form 10-K. February 14, 2019. Accessed March 27, 2019. www.freddiemac.com/investors/financials/

7 Ginnie Mae, “Ginnie Mae MBS Outstanding Increases to $2.056 Trillion.” Ginnie Mae. March 18, 2019. Accessed March 27, 2019. www.ginniemae.gov/newsroom/Pages/

8 Sullivan, Thomas, “A Tough Road: Cost To Develop One New Drug Is $2.6 Billion; Approval Rate for Drugs Entering Clinical Development is Less Than 12%.” Policy & Medicine. May 6, 2018. Accessed March 20, 2019. www.policymed.com/2014/12/

9 Fagnan, David E., Jose Maria Fernandez, Andrew W. Lo, and Roger M. Stein, “Can Financial Engineering Cure Cancer?.” American Economic Review: Papers & Proceedings 103(3) (2013). 406-411. alo.mit.edu/wp-content/uploads/2015/

10 Das, Sonya, Raphael Rousseau, Peter C. Adamson, and Andrew W. Lo, “New Business Models to Accelerate Innovation in Pediatric Oncology Therapeutics: A Review.” JAMA Oncology 4(9) (2018). 1274-1280. jamanetwork.com/journals/

11 Varma, Rohit, Thasarat S. Vajaranant, Bruce Burkemper, et al., “Visual Impairment and Blindness in Adults in the United States: Demographic and Geographic Variations From 2015 to 2050.” JAMA Ophthalmology 134(7) (2016). 802-809. jamanetwork.com/journals/.

12 National Federation of the Blind, “Blindness Statistics.” National Federation of the Blind. Updated January 2019. nfb.org/resources/blindness-statistics

13 Wittenborn, John and Daivd Rein, “Cost of Vision Problems: The Economic Burden of Vision Loss and Eye Disorders in the United States.” (Presentation, Prevent Blindness America, Chicago, IL, June 11, 2013). 58. www.preventblindness.org/sites/default/files/

14 World Health Organization, “Blindness and vision impairment.” World Health Organization. Updated October 11, 2018. www.who.int/news-room/fact-sheets/detail/

15 Segal, Julie, “The Asset Management Industry is Getting More Concentrated.” Institutional Investor. October 29, 2009. Accessed March 22, 2019. https://www.institutionalinvestor.com/article/

16 Amadeo, Kimberly, “FY 2019 Federal Budget: Trump’s Budget Request.” The Balance. March 13, 2019. Accessed March 22, 2019.  https://www.thebalance.com/

Author bio

The American Banker in 2012 dubbed Karen Shaw Petrou "the sharpest mind analyzing banking policy today – maybe ever.”  In 2017, the International Monetary Fund referred to her as “one of the most prominent non-governmental voices on financial regulation,” and in 2018 Bloomberg’s banking analyst described her as being “widely viewed by both sides of the bank regulation debate as incredibly smart.” 


Karen Shaw Petrou is the co-founder and Managing Partner of Federal Financial Analytics, Inc., a privately-held company that since 1985 has provided analytical and advisory services on legislative, regulatory, and public policy issues affecting financial services companies doing business in the U.S. and abroad. Central banks, financial regulators, vendors, and financial-industry investors also rely on the firm’s advisory services. The firm’s practice is a unique blend of strategic advice and policy analysis that does not include lobbying or any other projects that would compromise its objectivity and independence. 

Petrou is a frequent speaker on topics affecting the financial services industry. In addition to presentations to the U.S. Congress and U.S. government agencies, she has spoken before such organizations as the Japanese Diet, the Office of the Comptroller of the Currency, various Federal Reserve Banks, the Economist’s Buttonwood conference, the Securities Industry and Financial Markets Association, the American Bankers Association, The Clearing House, the Financial Services Roundtable, the Institute of International Bankers, the Conference of State Bank Supervisors, the Brookings Institution, and many other industry, academic, and policymaker audiences. She has also authored numerous articles in professional publications such as the American Banker and International Economy, as well as general-interest media like The New York Times and Wall Street Journal. Petrou appears frequently in the media as an expert on banking legislation and regulation. 

Prior to founding her own firm in 1985, Petrou worked in Washington as an officer at Bank of America, where she began her career in 1977. She is an honors graduate in Political Science from Wellesley College and also was a special student in an honors program at the Massachusetts Institute of Technology. She earned an M.A. in that subject from the University of California at Berkeley and was a doctoral candidate there. She has served on the boards of banking organizations and sits as a director on the board of the Foundation Fighting Blindness and the Fidelco Guide Dog Foundation.

Avery Tucker Fontaine is Head of Strategic Philanthropy for BNY Mellon Wealth Management as a component of Fiduciary Services. Avery supports the U.S. Markets, Family Office, Endowment & Foundation, and Planned Giving Groups to develop a holistic platform focused on exceeding client needs and expectations related to strategic philanthropy. Avery is the lead subject matter expert in the review and analysis of client philanthropic interests. She drives the effort for philanthropic thought leadership, education and training, tools and solutions, cross-functional teamwork, marketing support, and national association relationships. Avery works with partners across the U.S. Markets to deepen the effectiveness of our philanthropic solutions.  

Avery joined the firm in July 2014 and has almost 20 years of experience in the investment and financial services industry. Previously, she was Senior Vice President, Philanthropic Consultant, and Senior Vice President, Business Banking with Wachovia, then with Wells Fargo. As a Philanthropic Consultant, Avery worked with families and successful nonprofit institutions to improve grant-making efficacy, foundation & endowment management, use of planned giving, and long-term strategic planning. In Business Banking, Avery worked with C-level executives for both nonprofits and for-profits to create more efficient capitalization and cash flow via debt allocation, streamlining payables, payroll, and analyzing working capital. 

Avery holds a bachelor’s degree from Sewanee: University of the South and an MBA, Duke University. 

The American Banker in 2012 dubbed Karen Shaw Petrou "the sharpest mind analyzing banking policy today – maybe ever.”  In 2017, the International Monetary Fund referred to her as “one of the most prominent non-governmental voices on financial regulation,” and in 2018 Bloomberg’s banking analyst described her as being “widely viewed by both sides of the bank regulation debate as incredibly smart.” 


Karen Shaw Petrou is the co-founder and Managing Partner of Federal Financial Analytics, Inc., a privately-held company that since 1985 has provided analytical and advisory services on legislative, regulatory, and public policy issues affecting financial services companies doing business in the U.S. and abroad. Central banks, financial regulators, vendors, and financial-industry investors also rely on the firm’s advisory services. The firm’s practice is a unique blend of strategic advice and policy analysis that does not include lobbying or any other projects that would compromise its objectivity and independence. 

Petrou is a frequent speaker on topics affecting the financial services industry. In addition to presentations to the U.S. Congress and U.S. government agencies, she has spoken before such organizations as the Japanese Diet, the Office of the Comptroller of the Currency, various Federal Reserve Banks, the Economist’s Buttonwood conference, the Securities Industry and Financial Markets Association, the American Bankers Association, The Clearing House, the Financial Services Roundtable, the Institute of International Bankers, the Conference of State Bank Supervisors, the Brookings Institution, and many other industry, academic, and policymaker audiences. She has also authored numerous articles in professional publications such as the American Banker and International Economy, as well as general-interest media like The New York Times and Wall Street Journal. Petrou appears frequently in the media as an expert on banking legislation and regulation. 

Prior to founding her own firm in 1985, Petrou worked in Washington as an officer at Bank of America, where she began her career in 1977. She is an honors graduate in Political Science from Wellesley College and also was a special student in an honors program at the Massachusetts Institute of Technology. She earned an M.A. in that subject from the University of California at Berkeley and was a doctoral candidate there. She has served on the boards of banking organizations and sits as a director on the board of the Foundation Fighting Blindness and the Fidelco Guide Dog Foundation.

As part of The Social Innovations Journal’s special series, “The Social Innovations Finances Series,” Social Innovations Partners’ President Mike Clark interviewed leading bank analyst Karen Shaw Petrou to discuss her vision for the eradication of blindness and vision impairment through Eye Bonds and the future potential of this new fiscal instrument to partner groundbreaking research with needed financial support to change the future of health care.

Q: What are Eye Bonds? Can you explain the concept, how they are structured, etc. 

A: Eye Bonds would be new financial instruments authorized by new law to provide a limited federal guarantee to make it possible for institutional investors to fund projects, speeding treatments and cures for blindness. The legislation creates a five-year, $1 billion pilot to test this new construct and, if it works for blindness, pioneer a new way to speed treatments and cures across the spectrum of disease and disability.

Q: Why are the needed? How did you come to this solution? 

A: Eye Bonds and, more broadly, the Bio Bonds we hope come next, are needed because, quite simply, disease and disability are an urgent human and social-welfare problem that has yet to be advanced via innovative funding. There is now a deep, long “valley of death” between federal and philanthropic funding for basic research and the late-stage trials that prove whether a drug or device is safe and effective. All too much great science gets lost in this valley, delaying or even blocking treatments that would ease suffering, prolong life, and enhance independent living.

Q: What will help to make Eye Bond a reality? Our series is called IF (Innovation Finance). Finish this sentence: If (blank) happens, then Eye Bonds will become a reality (could be legislation, investment, etc.)…

A: Eye Bonds will be a reality if authorizing legislation is enhanced into law. Bipartisan legislation to do so is being introduced in the House and must then move through passage on the House floor and Senate consideration. President Trump would then need to sign it into law. At each of these steps, advocacy from patients, families, foundations, the financial industry, and public will make an amazing difference making this happen.

Q: If Eye Bonds are successful...what will that look like? What will the social impact be? Could this instrument be applied to other research fields? 

A: If Eye Bonds are successful, scientists tell us that the $1 billion of additional funding may be enough to cure blindness in a decade. That would be awesome enough. However, successful Eye Bonds will craft a new financial instrument useful across an array of disease and disabilities. As a result, quick action on many problems would result.  

For more information on the future of Eye Bonds and the full interview listen to the podcast here.

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